Detalhe da pesquisa
1.
Optimized arylomycins are a new class of Gram-negative antibiotics.
Nature
; 561(7722): 189-194, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30209367
2.
Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
Bioorg Med Chem Lett
; 26(15): 3518-24, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27346791
3.
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.
J Biol Chem
; 288(37): 26926-43, 2013 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23897821
4.
Lipid Tales: Optimizing Arylomycin Membrane Anchors.
ACS Med Chem Lett
; 14(11): 1524-1530, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974942
5.
Scintillation proximity assay as a high-throughput method to identify slowly dissociating nonpeptide ligand binding to the GnRH receptor.
J Biomol Screen
; 12(2): 235-9, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17208923
6.
A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties.
J Med Chem
; 49(13): 3753-6, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789729
7.
Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure-activity relationships and insurmountable antagonism.
Biochem Pharmacol
; 72(7): 838-49, 2006 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16930559
8.
Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function.
Mol Cell Endocrinol
; 259(1-2): 1-9, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-16987592
9.
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.
mBio
; 7(5)2016 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27601569
10.
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.
J Med Chem
; 59(11): 5520-41, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27167326
11.
Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.
J Med Chem
; 58(12): 5121-36, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26030457
12.
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
ACS Med Chem Lett
; 6(12): 1241-6, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26713112
13.
Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.
J Biomol Screen
; 17(2): 225-36, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21940710
14.
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.
PLoS One
; 7(1): e30376, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22253931
15.
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
PLoS One
; 7(12): e50864, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23227217
16.
A therapeutic antibody targeting BACE1 inhibits amyloid-ß production in vivo.
Sci Transl Med
; 3(84): 84ra43, 2011 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21613622
17.
A plate-based assay to measure cellular ERK substrate phosphorylation: utility for drug discovery of the MAPK-signaling cascade.
Assay Drug Dev Technol
; 8(4): 497-503, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20482377
18.
NMR structural characterization of a minimal peptide antagonist bound to the extracellular domain of the corticotropin-releasing factor1 receptor.
J Biol Chem
; 282(9): 6338-46, 2007 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17192263
19.
Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
Bioorg Med Chem Lett
; 17(9): 2535-9, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17329101
20.
Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Bioorg Med Chem Lett
; 17(8): 2171-8, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350839